https://enanomapper.adma.ai

• The Cusp database is publicly accessible.

• Click on CUSP icon to go to the CUSP database main project page

• Click on CUSP icon to go to the CUSP database main project page

Main project page

On the main page there are several links to the Search, Template Wizard, User guide (this page), etc.

Click on the Search link to go to the Search page

Search page

• On the search page there is a search box on the top right , a summary panel on the left and the results are shown at the main panel.

• The database includes results from multiple sources.

There are several summaries at the left panel:

• Project
• Study providers
• Nanomaterial type
• Nanomaterials
• Protocols
• Protocol annotation
• Method
• Method annotation
• P-Chem
• Tox
• Ecotox
• Cell
• Experiment year
• References
• Endpoint
• Endpoint annotation
• Release

Every panel is expandable and shows the types of elements found for the particular query

Expand the Projects panel and click on POLYRISK. This will filter the results and only data generated by POLYRISK project will be shown.

The filters can be combined.

Expand the Nanomaterial type panel and select black carbon. These are ontology terms assigned to each material , e.g. NPO_373

The panels show the types and counts of elements found for the particular query

i.e, the POLYRISK project and black carbon materials in this case.

The Methods panel shown indicate there is POLYRISK data for black carbon measured by these methods. The Method annotation panel contains the ontology terms denoting the same methods.

Exploring the data

Per material - click the Material and Study details link for particular material

Export data for all query results - Export tab

Compact summary report

• select Compact data report from the dropdown menu, click on XLSX icon and finally click on Download filtered entries as XLSX

The report is an Excel file

• Try exporting the same data into different report layouts (select from the dropdown menu).

Data export

Select the TXT icon and click on Download filtered entries as TSV

The result is a spreadsheet (.txt , tab separated text file)

Predefined queries

Select Physicochemical studies and click Apply. This will change the active query and will select all materials with physico-chemical characterisations.

This query could be further refined using the widgets at the left, and data exported as described.

Search by ontology terms

OBI_0302736 (comet assay) is a term defined in Ontology for Biomedical Investigations (OBI) BioPortal link

Summary

• Various types of graphical summaries are available at the Dashboard project page

• Download as image (SVG, PNG) or Excel files

Programmatic access (Application Programming Interface - API)

• API keys and OAuth2 plans

API documentation

• Online interactive API documentation with standard OpenAPI3 format

eNanoMapper client libraries

• Python : https://pypi.org/project/pynanomapper/
• R : https://github.com/enanomapper/renm
• JavaScript : https://github.com/enanomapper/ambit.js/
• JavaScript : https://github.com/ideaconsult/jToxKit

Jupyter notebooks

https://github.com/ideaconsult/notebooks-ambit/blob/master/enanomapper/tutorial.ipynb https://github.com/ideaconsult/notebooks-ambit/blob/master/enanomapper/summary.ipynb https://github.com/ideaconsult/notebooks-ambit/blob/master/enanomapper/explore.ipynb

Summary charts generated with explore.ipynb

Data entry

The data entry for eNanoMapper and the Template Wizard are described in this tutorial.

This guide is available at Help/User guide